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Rhodiola rosea

Rhodiola rosea may be effective for improving mood and alleviating depression. Pilot studies on human subjects showed that it improves physical and mental performance and that it may reduce fatigue.

Rhodiola rosea's effects could be related to optimising serotonin and dopamine levels due to monoamine oxidase inhibition and its influence on opioid peptides such as beta-endorphins, although these specific neurochemical mechanisms have not been clearly documented with scientific studies.

Rhodiola is included among a class of plant derivatives called adaptogens which differ from chemical stimulants, such as nicotine, and do not have the same physiological effects.

In Russia and Scandinavia, Rhodiola rosea has been used for centuries to cope with the cold Siberian climate and stressful life. Rhodiola has been used in traditional Chinese medicine, where it is called hóng j?ng ti?n.

Rhodiola rosea contains a variety of compounds that may contribute to its effects, including the class of rosavins which include rosavin, rosarin, and rosin. Several studies have suggested that the most active components are likely to be rhodioloside and tyrosol, with other components being inactive when administered alone, but showing synergistic effects when a fixed combination of rhodioloside, rosavin, rosarin and rosin was used.

While animal tests have suggested a variety of beneficial effects for Rhodiola rosea extracts, only for depression is there scientific evidence for Rhodiola components having anti-disease benefits in humans. A clinical trial showed significant effect for a Rhodiola extract in doses of 340?680 mg per day in male and female patients from 18 to 70 years old with mild to moderate depression.

Rhodiola rosea extract SHR-5 exerts an anti-fatigue effect that increases mental performance. In studies, Rhodiola significantly reduced symptoms of fatigue and improved attention after four weeks of repeated administration.

A typical dosage is one or two capsules or tablets daily; one in the morning and, when taking two, one in the early afternoon. Rhodiola rosea should be taken early in the day because for some it can interfere with sleep. Others can take it in the evening with no effect on sleep patterns. If a user becomes overly activated, jittery or agitated then a smaller dose with very gradual increases may be needed. It is contraindicated in excited states.

The dose may be increased to 200 mg three times a day if needed. A high dose is considered to be daily intakes of 1,000 mg and above.

Rhodiola rosea may be beneficial to increase energy and mental performance for people suffering from Hashimoto's disease.

In a 2007 clinical trial from Armenia, total effective doses were in the range of 340-680 mg per day for people aged 18 to 70. No side-effects were demonstrated, at these doses, in the treatment of mild-to-moderate depression.

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